Kosuke Ebina Selected Research

Osteoporosis

3/2024	The 2023 Guidelines for the management and treatment of glucocorticoid-induced osteoporosis.
2/2024	Iguratimod suppresses sclerostin and receptor activator of NF-κB ligand production via the extracellular signal-regulated kinase/early growth response protein 1/tumor necrosis factor alpha pathway in osteocytes and ameliorates disuse osteoporosis in mice.
1/2024	An investigation of the differential therapeutic effects of romosozumab on postmenopausal osteoporosis patients with or without rheumatoid arthritis complications: a case-control study.
11/2023	Anti-NF-κB peptide derived from nuclear acidic protein attenuates ovariectomy-induced osteoporosis in mice.
3/2023	Baseline serum PINP level is associated with the increase in hip bone mineral density seen with Romosozumab treatment in previously untreated women with osteoporosis.
11/2022	Low serum albumin concentration is associated with increased risk of osteoporosis in postmenopausal patients with rheumatoid arthritis.
11/2022	Impact of the duration of previous osteoporosis treatment on the effect of romosozumab in patients with postmenopausal osteoporosis.
7/2022	The real-world effectiveness of anti-RANKL antibody denosumab on the clinical fracture prevention in patients with rheumatoid arthritis: The ANSWER cohort study.
10/2021	Effects of prior osteoporosis treatment on 12-month treatment response of romosozumab in patients with postmenopausal osteoporosis.
7/2021	Effects of iguratimod on glucocorticoid-induced disorder of bone metabolism in vitro.

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Kosuke Ebina Research Topics

Disease

55	Rheumatoid Arthritis 05/2024 - 04/2009
19	Osteoporosis 03/2024 - 09/2013
13	Congenital Abnormalities (Deformity) 01/2024 - 11/2017
8	Postmenopausal Osteoporosis 01/2024 - 09/2017
7	Hallux Valgus 08/2023 - 05/2018
4	Inflammation (Inflammations) 11/2022 - 01/2009
4	Arthritis (Polyarthritis) 10/2022 - 01/2009
3	Necrosis 05/2024 - 01/2023
3	Osteoarthritis 01/2024 - 01/2020
3	Pain (Aches) 01/2022 - 01/2020
3	Bone Resorption 07/2021 - 12/2016
2	Rheumatic Diseases (Rheumatism) 07/2023 - 07/2022
2	Infections 06/2023 - 02/2022
2	Wounds and Injuries (Trauma) 06/2023 - 01/2020
2	Experimental Arthritis 10/2022 - 01/2009
1	Hypertension (High Blood Pressure) 05/2024
1	Flatfoot (Flat Feet) 01/2024
1	Bursitis (Adhesive Capsulitis) 08/2023
1	Neoplasms (Cancer) 08/2023
1	Joint Diseases (Joint Disease) 11/2022
1	Low Back Pain (Lumbago) 12/2020
1	Osteoporotic Fractures 09/2020
1	Ankylosis 09/2018
1	Crush Injuries 05/2018
1	Hyperlipidemias (Hyperlipidemia) 01/2018

Drug/Important Bio-Agent (IBA)

15	Antirheumatic Agents (DMARD)IBA 05/2024 - 12/2012
11	Janus Kinase InhibitorsIBA 05/2024 - 01/2020
6	romosozumabIBA 01/2024 - 11/2020
6	Denosumab FDA Link 07/2022 - 01/2017
5	GlucocorticoidsIBA 03/2024 - 10/2020
5	Teriparatide (Parathar)FDA Link 03/2021 - 12/2016
4	Methotrexate (Mexate)FDA LinkGeneric 05/2024 - 07/2019
4	glucose utilization inhibitor (IGU)IBA 02/2024 - 07/2019
4	Diphosphonates (Bisphosphonates)IBA 03/2021 - 01/2017
4	tocilizumab (atlizumab)FDA Link 09/2020 - 12/2012
3	Interleukin-6 Receptors (Interleukin 6 Receptor)IBA 05/2024 - 01/2023
3	AntibodiesIBA 05/2024 - 01/2009
3	Tumor Necrosis Factor-alpha (Tumor Necrosis Factor)IBA 02/2024 - 12/2012
3	iguratimodIBA 02/2024 - 07/2019
3	Monoclonal AntibodiesIBA 07/2022 - 09/2020
3	Tumor Necrosis Factor InhibitorsIBA 01/2022 - 01/2021
2	MineralsIBA 03/2024 - 03/2023
2	LigandsIBA 02/2024 - 10/2020
2	cyclic citrullinated peptideIBA 01/2024 - 02/2020
2	Therapeutic UsesIBA 01/2024 - 01/2009
2	Proteins (Proteins, Gene)FDA Link 11/2023 - 12/2011
2	Interleukin-6 InhibitorsIBA 06/2023 - 01/2021
2	Prednisolone (Predate)FDA LinkGeneric 11/2022 - 03/2013
2	CytokinesIBA 11/2022 - 01/2009
2	tofacitinibIBA 07/2021 - 01/2020
2	Abatacept (Orencia)FDA Link 07/2021 - 09/2020
2	1- hydroxy- 5,8- bis(2- ((2- hydroxyethyl)amino)ethylamino)- 9,10- anthracenedioneIBA 01/2021 - 03/2013
2	Capsules (Microcapsules)IBA 01/2020 - 05/2018
2	Oxygen (Dioxygen)IBA 05/2018 - 12/2011
2	Vitamin K 2 (Vitamin K2)IBA 05/2016 - 09/2013
2	Interleukin-6 (Interleukin 6)IBA 07/2014 - 12/2012
2	Messenger RNA (mRNA)IBA 12/2011 - 01/2009
2	AdiponectinIBA 04/2009 - 01/2009
1	Rheumatoid FactorIBA 05/2024
1	SteroidsIBA 03/2024
1	Early Growth Response Protein 1IBA 02/2024
1	Extracellular Signal-Regulated MAP Kinases (Extracellular Signal Regulated Kinases)IBA 02/2024
1	ametantrone (HAQ)IBA 01/2024
1	Peptides (Polypeptides)IBA 11/2023
1	Immunoglobulins (Immunoglobulin)IBA 06/2023
1	AntigensIBA 06/2023
1	SiliconesIBA 01/2023
1	CTLA-4 AntigenIBA 01/2023
1	CD100 antigenIBA 11/2022
1	Indicators and Reagents (Reagents)IBA 11/2022
1	C-Reactive ProteinIBA 11/2022
1	Serum AlbuminIBA 11/2022
1	Adalimumab (Humira)FDA Link 10/2022
1	Immunoglobulin FragmentsIBA 01/2022
1	Dexamethasone (Maxidex)FDA LinkGeneric 07/2021
1	baricitinibIBA 07/2021
1	sarilumabIBA 07/2021
1	NF-kappa B (NF-kB)IBA 07/2021
1	Tumor Necrosis Factor Receptors (Tumor Necrosis Factor Receptor)IBA 07/2021
1	TNF Receptor-Associated Factor 6 (TRAF6)IBA 07/2021
1	Thiostrepton (Gargon)IBA 12/2019
1	Apolipoprotein E3IBA 01/2018
1	Protein Isoforms (Isoforms)IBA 01/2018
1	Apolipoprotein E4IBA 01/2018

Therapy/Procedure

13	Osteotomy 01/2024 - 11/2017
11	Arthroplasty 01/2024 - 01/2017
8	Therapeutics 03/2024 - 12/2012
2	Operative Surgical Procedures 01/2022 - 10/2021
2	Arthrodesis 12/2018 - 05/2018
2	Replacement Arthroplasty 09/2017 - 01/2017
1	Postoperative Care 01/2024
1	Intraperitoneal Injections 11/2023
1	Ovariectomy (Oophorectomy) 11/2023
1	Debridement 06/2023
1	Local Anesthesia 06/2023
1	Subcutaneous Injections 10/2022
1	Aftercare (After-Treatment) 01/2022
1	Reoperation 10/2021
1	Activities of Daily Living (ADL) 01/2021
1	Sutures (Suture) 01/2020